Genetics and Genomics: Epigenetics, Environment, and Ethics
Discoveries based on awareness of the genomes of literally thousands of organisms inhabiting this planet have facilitated renewed emphasis on the study of life and its meaning in the social sciences and humanities as well as in the life sciences. For every individual, experiencing and living the implications of such scientific discoveries depends on understanding the social and personal complexity embedded within the many contexts and filters applied to genomic information – in research labs, in ethics debates dealing with emerging technological capabilities, in genome databases, in social interactions, and in policy deliberations. The goal of this cluster is to explore the genome sciences in many contexts and to help students explore the biomedical, biological, historical, technological, and ethical implications of genomic advances, as well as the questions that such advances pose for understanding our past and contemplating the future of biomedicine. Each of the courses in the cluster will explore this theme from a different perspective, enabling students to evaluate the issues that we face as a society, as potential future scientists, and as individual citizens. In all four courses, students will spend significant time reading and discussing the primary scientific literature, as well as interacting via small group activities and journal club-style presentations. This cluster is designed for students with widely varied interests to potential STEM majors who want to understand the basic science, biomedical, and social implications of their future work.
Molecular Genetics and Microbiology 222FS — Genetics and Epigenetics: The codes that control our genomes (NS)
Beth Sullivan, Associate Professor in Molecular Genetics and Microbiology
Many inherited cellular and physiological traits in humans are not due to changes in DNA sequence, but instead are shaped by factors such as age, diet, or environment. This course will examine sequence-independent regulation of the human genome, non-genetic diseases, environmental factors that influence or control the epigenome, and multi-generational inheritance of epigenetic information (i.e. how grandparental experiences shape descendants’ genomes). It will also cover genome engineering and genome editing for therapy and disease correction. This course involves extensive reading of the primary literature (historical and current) and will be anchored on human genetics, although model systems (mouse, roundworm, fruit fly) will also be discussed. Open to students in the FOCUS program only. Instructor: Beth Sullivan.
Environment 148FS/Biology 148FS/Genome 148FS — Genomics of host-microbe interactions: The symbiotic web (NS, R, STS)
Francois Lutzoni, Professor of Biology
Genomic approaches have uncovered a microbial world of astonishing diversity, including numerous microbes that interact with hosts. Our own bodies contain 10 times more bacterial cells than human cells and 150 times more bacterial genes than human genes. A deeper appreciation of microbial interactions is revolutionizing our understanding of life’s history, ecology, and human health. This course will explore how hosts and microbes affect each other’s genomes, trajectories of parasitism and mutualism, ecological significance of microbial symbionts of plants, fungi, and animals, as well as molecular and cellular mechanisms of homeostasis. Open only to students in the FOCUS program.
Molecular Genetics and Microbiology 120FS/Public Policy 186FS — Ethics of Genome Research (EI, STS, SS)
Susanne Haga, Associate Professor at Duke University School of Medicine, Center for Applied Genomics and Precision Medicine
This course will examine the ethical implications raised by genetic and genomic research. Students will gain an understanding of historical basis of human subjects protections in the U.S., the ethical pillars of research, and the issues that arise from genetics and genomics research. Case studies in genomics research will be used to illustrate various ethical implications. Reading will consist of review papers of the history of human subjects protections, federal regulations of human subjects protections, actual informed consent documents, and scientific papers from the primary scientific literature to illustrate the nature of modern research in this field. Open only to students in the FOCUS program.
Biology 208 FS: Computing on the Genome: An Introduction to Genomics and Bioinformatics (NS, QS)
Paul Magwene, Associate Professor of Biology
This course will provide an introduction to key concepts of the genome sciences, using tools and concepts from computational biology and bioinformatics. Topics to be covered include genome structure, function, variation, and evolution. Students will learn to how apply basic computational and statistical methods for describing and quantifying various aspects of genome biology and will apply these tools to real world data. No prior programming or statistical experience is required. Open only to students in the FOCUS program.
- Associate Professor of Molecular Genetics and Microbiology